Publications

Comparative biochemical and structural analysis of the flavin-binding dodecins from Streptomyces davaonensis and Streptomyces coelicolor reveals striking differences with regard to multimerization

Microbiology 2019 Jul 24
Bourdeaux F, Ludwig P, Paithankar K, Sander B, Essen LO, Grininger M, Mack M

Protein denaturation at the air-water interface and how to prevent it

Elife 2019 Apr 1;8
D'Imprima E, Floris D, Joppe M, Sánchez R, Grininger M, Kühlbrandt W

Fatty Acid Biosynthesis: Chain-Length Regulation and Control

Chembiochem 2019 Mar 25
Heil CS, Wehrheim SS, Paithankar KS, Grininger M

Engineering of Chimeric Polyketide Synthases Using SYNZIP Docking Domains

ACS Chem Biol 2019 Mar 15;14(3):426-433
Klaus M, D'Souza AD, Nivina A, Khosla C, Grininger M

Probing the modularity of megasynthases by rational engineering of a fatty acid synthase Type I

Protein Sci 2019 Feb;28(2):414-428
Rittner A, Paithankar KS, Drexler DJ, Himmler A, Grininger M

Site-Specific Labelling of Multidomain Proteins by Amber Codon Suppression

Sci Rep 2018 Oct 5;8(1):14864
Heil CS, Rittner A, Goebel B, Beyer D, Grininger M

Analysis and engineering of substrate shuttling by the acyl carrier protein (ACP) in fatty acid synthases (FASs)

Chem Commun (Camb) 2018 Oct 11;54(82):11606-11609
Rossini E, Gajewski J, Klaus M, Hummer G, Grininger M

Engineering strategies for rational polyketide synthase design

An engineered fatty acid synthase combined with a carboxylic acid reductase enables de novo production of 1-octanol in Saccharomyces cerevisiae

Biotechnol Biofuels 2018 Jun 1;11:150
Henritzi S, Fischer M, Grininger M, Oreb M, Boles E

Characterization of the small flavin-binding dodecin in the roseoflavin producer Streptomyces davawensis

Microbiology 2018 Jun;164(6):908-919
Ludwig P, Sévin DC, Busche T, Kalinowski J, Bourdeaux F, Grininger M, Mack M

Flavin Storage and Sequestration by Mycobacterium tuberculosis Dodecin

ACS Infect Dis 2018 Jul 13;4(7):1082-1092
Bourdeaux F, Hammer CA, Vogt S, Schweighöfer F, Nöll G, Wachtveitl J, Grininger M

Characterization of the Polyspecific Transferase of Murine Type I Fatty Acid Synthase (FAS) and Implications for Polyketide Synthase (PKS) Engineering

ACS Chem Biol 2018 Mar 16;13(3):723-732
Rittner A, Paithankar KS, Huu KV, Grininger M

Strategies in megasynthase engineering - fatty acid synthases (FAS) as model proteins

Engineering fungal de novo fatty acid synthesis for short chain fatty acid production

Nat Commun 2017 Mar 10;8:14650
Gajewski J, Pavlovic R, Fischer M, Boles E, Grininger M

Engineering fatty acid synthases for directed polyketide production

Nat Chem Biol 2017 Apr;13(4):363-365
Gajewski J, Buelens F, Serdjukow S, Janßen M, Cortina N, Grubmüller H, Grininger M

Expanding the product portfolio of fungal type I fatty acid synthases

Nat Chem Biol 2017 Apr;13(4):360-362
Zhu Z, Zhou YJ, Krivoruchko A, Grininger M, Zhao ZK, Nielsen J

Crystallization and X-ray diffraction studies of a complete bacterial fatty-acid synthase type I

Acta Crystallogr F Struct Biol Commun 2015 Nov;71(Pt 11):1401-7
Enderle M, McCarthy A, Paithankar KS, Grininger M

Cryo-EM structure of fatty acid synthase (FAS) from Rhodosporidium toruloides provides insights into the evolutionary development of fungal FAS

Protein Sci 2015 Jun;24(6):987-95
Fischer M, Rhinow D, Zhu Z, Mills DJ, Zhao ZK, Vonck J, Grininger M

Multi-Ligand-Binding Flavoprotein Dodecin as a Key Element for Reversible Surface Modification in Nano-biotechnology

ACS Nano 2015;9(4):3491-500
Gutiérrez Sánchez C, Su Q, Schönherr H, Grininger M, Nöll G

Modular polyketide synthases (PKSs): a new model fits all? Chembiochem

2014 Nov 24;15(17):2489-93 doi: 10
Rittner A, Grininger M

Perspectives on the evolution, assembly and conformational dynamics of fatty acid synthase type I (FAS I) systems

Directed manipulation of a flavoprotein photocycle

Angew Chem Int Ed Engl 2013 Aug 5;52(32):8463-6
Staudt H, Hoesl MG, Dreuw A, Serdjukow S, Oesterhelt D, Budisa N, Wachtveitl J, Grininger M

Structure and conformational variability of the mycobacterium tuberculosis fatty acid synthase multienzyme complex

Structure 2013 Jul 2;21(7):1251-7
Ciccarelli L, Connell SR, Enderle M, Mills DJ, Vonck J, Grininger M

The flavoprotein dodecin as a redox probe for electron transfer through DNA

Angew Chem Int Ed Engl 2013 Apr 26;52(18):4950-3
Yu Y, Heidel B, Parapugna TL, Wenderhold-Reeb S, Song B, Schönherr H, Grininger M, Nöll G

Ultrafast excited-state deactivation of flavins bound to dodecin

J Biol Chem 2012 May 18;287(21):17637-44
Staudt H, Oesterhelt D, Grininger M, Wachtveitl J

Mechanism of substrate shuttling by the acyl-carrier protein within the fatty acid mega-synthase

J Am Chem Soc 2010 Sep 8;132(35):12357-64
Anselmi C, Grininger M, Gipson P, Faraldo-Gómez JD

Structural and biochemical characterization of a halophilic archaeal alkaline phosphatase

J Mol Biol 2010 Jul 2;400(1):52-62
Wende A, Johansson P, Vollrath R, Dyall-Smith M, Oesterhelt D, Grininger M

Electrochemical switching of the flavoprotein dodecin at gold surfaces modified by flavin-DNA hybrid linkers

Biointerphases 2008 Sep;3(3):51-8
Grininger M, Nöll G, Trawöger S, Sinner EK, Oesterhelt D

Direct structural insight into the substrate-shuttling mechanism of yeast fatty acid synthase by electron cryomicroscopy

Proc Natl Acad Sci U S A 2010 May 18;107(20):9164-9
Gipson P, Mills DJ, Wouts R, Grininger M, Vonck J, Kühlbrandt W

Multimeric options for the auto-activation of the Saccharomyces cerevisiae FAS type I megasynthase

Structure 2009 Aug 12;17(8):1063-74
Johansson P, Mulinacci B, Koestler C, Vollrath R, Oesterhelt D, Grininger M

Blue-light-triggered photorelease of active chemicals captured by the flavoprotein dodecin

Chembiochem 2009 Mar 23;10(5):834-7
Nöll G, Trawöger S, von Sanden-Flohe M, Dick B, Grininger M

Dodecin is the key player in flavin homeostasis of archaea

J Biol Chem 2009 May 8;284(19):13068-76
Grininger M, Staudt H, Johansson P, Wachtveitl J, Oesterhelt D

Inhibition of the fungal fatty acid synthase type I multienzyme complex

Proc Natl Acad Sci U S A 2008 Sep 2;105(35):12803-8
Johansson P, Wiltschi B, Kumari P, Kessler B, Vonrhein C, Vonck J, Oesterhelt D, Grininger M

Dodecin sequesters FAD in closed conformation from the aqueous solution

J Mol Biol 2006 Dec 8;364(4):561-6
Grininger M, Seiler F, Zeth K, Oesterhelt D

Dodecins: a family of lumichrome binding proteins

J Mol Biol 2006 Mar 31;357(3):842-57
Grininger M, Zeth K, Oesterhelt D

Parameters affecting the X-ray dose absorbed by macromolecular crystals

J Synchrotron Radiat 2005 May;12(Pt 3):268-75
Murray JW, Rudiño-Piñera E, Owen RL, Grininger M, Ravelli RB, Garman EF

Expression, crystallization and crystallographic analysis of DegS, a stress sensor of the bacterial periplasm

Acta Crystallogr D Biol Crystallogr 2004 Aug;60(Pt 8):1429-31
Grininger M, Ravelli RB, Heider U, Zeth K

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