The Role of the Iterative Modules in Polyketide Synthase Evolution

The resolution revolution in cryoEM requires high-quality sample preparation: a rapid pipeline to a high-resolution map of yeast fatty acid synthase

IUCrJ 2020 Jan 25;7(Pt 2):220-227
Joppe M, D'Imprima E, Salustros N, Paithankar KS, Vonck J, Grininger M, Kühlbrandt W

Analysis of the co-translational assembly of the fungal fatty acid synthase (FAS)

Sci Rep 2020 Jan 21;10(1):895
Fischer M, Joppe M, Mulinacci B, Vollrath R, Konstantinidis K, Kötter P, Ciccarelli L, Vonck J, Oesterhelt D, Grininger M

Type I fatty acid synthase trapped in the octanoyl-bound state

Protein Sci 2020 Feb;29(2):589-605
Rittner A, Paithankar KS, Himmler A, Grininger M

Structure of the archaeal chemotaxis protein CheY in a domain-swapped dimeric conformation

Acta Crystallogr F Struct Biol Commun 2019 Sep 1;75(Pt 9):576-585
Paithankar KS, Enderle M, Wirthensohn DC, Miller A, Schlesner M, Pfeiffer F, Rittner A, Grininger M, Oesterhelt D

Comparative biochemical and structural analysis of the flavin-binding dodecins from Streptomyces davaonensis and Streptomyces coelicolor reveals striking differences with regard to multimerization

Microbiology 2019 Oct;165(10):1095-1106
Bourdeaux F, Ludwig P, Paithankar K, Sander B, Essen LO, Grininger M, Mack M

Protein denaturation at the air-water interface and how to prevent it

Elife 2019 Apr 1;8
D'Imprima E, Floris D, Joppe M, Sánchez R, Grininger M, Kühlbrandt W

Fatty Acid Biosynthesis: Chain-Length Regulation and Control

Chembiochem 2019 Sep 16;20(18):2298-2321
Heil CS, Wehrheim SS, Paithankar KS, Grininger M

Engineering of Chimeric Polyketide Synthases Using SYNZIP Docking Domains

ACS Chem Biol 2019 Mar 15;14(3):426-433
Klaus M, D'Souza AD, Nivina A, Khosla C, Grininger M

Probing the modularity of megasynthases by rational engineering of a fatty acid synthase Type I

Protein Sci 2019 Feb;28(2):414-428
Rittner A, Paithankar KS, Drexler DJ, Himmler A, Grininger M

Site-Specific Labelling of Multidomain Proteins by Amber Codon Suppression

Sci Rep 2018 Oct 5;8(1):14864
Heil CS, Rittner A, Goebel B, Beyer D, Grininger M

Analysis and engineering of substrate shuttling by the acyl carrier protein (ACP) in fatty acid synthases (FASs)

Chem Commun (Camb) 2018 Oct 11;54(82):11606-11609
Rossini E, Gajewski J, Klaus M, Hummer G, Grininger M

Engineering strategies for rational polyketide synthase design

An engineered fatty acid synthase combined with a carboxylic acid reductase enables de novo production of 1-octanol in Saccharomyces cerevisiae

Biotechnol Biofuels 2018 Jun 1;11:150
Henritzi S, Fischer M, Grininger M, Oreb M, Boles E

Characterization of the small flavin-binding dodecin in the roseoflavin producer Streptomyces davawensis

Microbiology 2018 Jun;164(6):908-919
Ludwig P, Sévin DC, Busche T, Kalinowski J, Bourdeaux F, Grininger M, Mack M

Flavin Storage and Sequestration by Mycobacterium tuberculosis Dodecin

ACS Infect Dis 2018 Jul 13;4(7):1082-1092
Bourdeaux F, Hammer CA, Vogt S, Schweighöfer F, Nöll G, Wachtveitl J, Grininger M

Characterization of the Polyspecific Transferase of Murine Type I Fatty Acid Synthase (FAS) and Implications for Polyketide Synthase (PKS) Engineering

ACS Chem Biol 2018 Mar 16;13(3):723-732
Rittner A, Paithankar KS, Huu KV, Grininger M

Strategies in megasynthase engineering - fatty acid synthases (FAS) as model proteins

Engineering fungal de novo fatty acid synthesis for short chain fatty acid production

Nat Commun 2017 Mar 10;8:14650
Gajewski J, Pavlovic R, Fischer M, Boles E, Grininger M

Engineering fatty acid synthases for directed polyketide production

Nat Chem Biol 2017 Apr;13(4):363-365
Gajewski J, Buelens F, Serdjukow S, Janßen M, Cortina N, Grubmüller H, Grininger M

Expanding the product portfolio of fungal type I fatty acid synthases

Nat Chem Biol 2017 Apr;13(4):360-362
Zhu Z, Zhou YJ, Krivoruchko A, Grininger M, Zhao ZK, Nielsen J

Crystallization and X-ray diffraction studies of a complete bacterial fatty-acid synthase type I

Acta Crystallogr F Struct Biol Commun 2015 Nov;71(Pt 11):1401-7
Enderle M, McCarthy A, Paithankar KS, Grininger M

Cryo-EM structure of fatty acid synthase (FAS) from Rhodosporidium toruloides provides insights into the evolutionary development of fungal FAS

Protein Sci 2015 Jun;24(6):987-95
Fischer M, Rhinow D, Zhu Z, Mills DJ, Zhao ZK, Vonck J, Grininger M

Multi-Ligand-Binding Flavoprotein Dodecin as a Key Element for Reversible Surface Modification in Nano-biotechnology

ACS Nano 2015;9(4):3491-500
Gutiérrez Sánchez C, Su Q, Schönherr H, Grininger M, Nöll G

Modular polyketide synthases (PKSs): a new model fits all? Chembiochem

2014 Nov 24;15(17):2489-93 doi: 10
Rittner A, Grininger M

Perspectives on the evolution, assembly and conformational dynamics of fatty acid synthase type I (FAS I) systems

Directed manipulation of a flavoprotein photocycle

Angew Chem Int Ed Engl 2013 Aug 5;52(32):8463-6
Staudt H, Hoesl MG, Dreuw A, Serdjukow S, Oesterhelt D, Budisa N, Wachtveitl J, Grininger M

Structure and conformational variability of the mycobacterium tuberculosis fatty acid synthase multienzyme complex

Structure 2013 Jul 2;21(7):1251-7
Ciccarelli L, Connell SR, Enderle M, Mills DJ, Vonck J, Grininger M

The flavoprotein dodecin as a redox probe for electron transfer through DNA

Angew Chem Int Ed Engl 2013 Apr 26;52(18):4950-3
Yu Y, Heidel B, Parapugna TL, Wenderhold-Reeb S, Song B, Schönherr H, Grininger M, Nöll G

Ultrafast excited-state deactivation of flavins bound to dodecin

J Biol Chem 2012 May 18;287(21):17637-44
Staudt H, Oesterhelt D, Grininger M, Wachtveitl J

Mechanism of substrate shuttling by the acyl-carrier protein within the fatty acid mega-synthase

J Am Chem Soc 2010 Sep 8;132(35):12357-64
Anselmi C, Grininger M, Gipson P, Faraldo-Gómez JD

Structural and biochemical characterization of a halophilic archaeal alkaline phosphatase

J Mol Biol 2010 Jul 2;400(1):52-62
Wende A, Johansson P, Vollrath R, Dyall-Smith M, Oesterhelt D, Grininger M

Electrochemical switching of the flavoprotein dodecin at gold surfaces modified by flavin-DNA hybrid linkers

Biointerphases 2008 Sep;3(3):51-8
Grininger M, Nöll G, Trawöger S, Sinner EK, Oesterhelt D

Direct structural insight into the substrate-shuttling mechanism of yeast fatty acid synthase by electron cryomicroscopy

Proc Natl Acad Sci U S A 2010 May 18;107(20):9164-9
Gipson P, Mills DJ, Wouts R, Grininger M, Vonck J, Kühlbrandt W

Multimeric options for the auto-activation of the Saccharomyces cerevisiae FAS type I megasynthase

Structure 2009 Aug 12;17(8):1063-74
Johansson P, Mulinacci B, Koestler C, Vollrath R, Oesterhelt D, Grininger M

Blue-light-triggered photorelease of active chemicals captured by the flavoprotein dodecin

Chembiochem 2009 Mar 23;10(5):834-7
Nöll G, Trawöger S, von Sanden-Flohe M, Dick B, Grininger M

Dodecin is the key player in flavin homeostasis of archaea

J Biol Chem 2009 May 8;284(19):13068-76
Grininger M, Staudt H, Johansson P, Wachtveitl J, Oesterhelt D

Inhibition of the fungal fatty acid synthase type I multienzyme complex

Proc Natl Acad Sci U S A 2008 Sep 2;105(35):12803-8
Johansson P, Wiltschi B, Kumari P, Kessler B, Vonrhein C, Vonck J, Oesterhelt D, Grininger M

Dodecin sequesters FAD in closed conformation from the aqueous solution

J Mol Biol 2006 Dec 8;364(4):561-6
Grininger M, Seiler F, Zeth K, Oesterhelt D

Dodecins: a family of lumichrome binding proteins

J Mol Biol 2006 Mar 31;357(3):842-57
Grininger M, Zeth K, Oesterhelt D

Parameters affecting the X-ray dose absorbed by macromolecular crystals

J Synchrotron Radiat 2005 May;12(Pt 3):268-75
Murray JW, Rudiño-Piñera E, Owen RL, Grininger M, Ravelli RB, Garman EF

Expression, crystallization and crystallographic analysis of DegS, a stress sensor of the bacterial periplasm

Acta Crystallogr D Biol Crystallogr 2004 Aug;60(Pt 8):1429-31
Grininger M, Ravelli RB, Heider U, Zeth K

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